Evolution of C . diphtheriae strains during different phases of the diphtheria epidemic in
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چکیده
Valentina Kolodkina, Leonid Titov, Tatyana Sharapa, Francine Grimont, Patrick AD Grimont, Androulla Efstratiou 1 Belarusian Research Institute for Epidemiology and Microbiology, Minsk, Belarus; 2 Centre National de Reference pour Corynebacterium diphtheriae, Unite de Biodiversite des Bacteries Pathogenes Emergentes INSERM U 389, Institute Pasteur, Paris, France; 3 HPA/WHO Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, London, UK;
منابع مشابه
Molecular epidemiology of C. diphtheriae strains during different phases of the diphtheria epidemic in Belarus
BACKGROUND The reemergence of epidemic diphtheria in Belarus in 1990s has provided us with important information on the biology of the disease and the diversity of the causative agent Corynebacterium diphtheriae. Molecular investigations were conducted with the aim to analyze the genetic variability of C diphtheriae during the post-epidemic period. METHODS The biotype and toxigenicity status ...
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Background and Objective: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring until today. One of the causes is probably the diphtheria toxin repressor (dtxR) gene which influences toxin expression. Therefore, in this study the characterization of the gene was performed to determine the mutations that affect the DtxR protein. Methods: The dtxR genes of ...
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Sixty-six Corynebacterium diphtheriae strains (62 of the gravis biotype and 4 of the mitis biotype) isolated during the Georgian diphtheria epidemic of 1993 to 1998 and 13 non-Georgian C. diphtheriae strains (10 Russian and 3 reference isolates) were characterized by (i) biotyping, (ii) toxigenicity testing with the Elek assay and PCR, (iii) the randomly amplified polymorphic DNA (RAPD) techniq...
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BACKGROUND Corynebacterium diphtheriae is a re-emerging pathogen in Europe causing invasive infections in vaccinated persons and classical diphtheria in unvaccinated persons. In the presented study we analysed genetic changes in C. diphtheriae isolates collected in Poland from the period before the introduction of the mass anti-diphtheria vaccination to the present time when over 98% of the pop...
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The massive reemergence of diphtheria in the Newly Independent States of the former Soviet Union marked the first large-scale diphtheria epidemic in industrialized countries in 3 decades. Factors contributing to the epidemic included a large population of susceptible adults; decreased childhood immunization, which compromised what had been a well-established childhood vaccination program; subop...
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تاریخ انتشار 2006